Deadpool, Vol. 1 #4 (Cvr A) (1994)

Mano @ Mano
Deadpool and company break into Black Tom's base, where Deadpool learns why he's been targeted: the doctor helping Black Tom is Dr. Killbrew, the man who made Deadpool into the regenerative mess he is today. During the fracas, he's able to pull most of their butts out of the fire, starting with his own. He also discovers what it really takes to stop the Juggernaut.
Release Date: 1994