Daredevil, Vol. 1 #252 (1988)

The Fall of the Mutants - Ground Zero
Apocalypse has brought his attack to bear on the population, and the clinic Karen and Matt provide becomes ground zero for the defense of the common man. It's up to Daredevil and the Black Widow to help hold things together in the streets long enough for the cavalry to arrive and the craziness to blow over.
Release Date: 1988