Deadpool, Vol. 3 #15 (2009)

Want You To Want Me, Part One: The Complete Idiot's Guide To Metaphors
Deadpool has been rich and famous, but now he's merely infamous. He comes back to the mainland looking for acceptance, and starts his search in San Fransisco. Once there, he has an epiphany which will likely terrify those who know him best.
Release Date: 2009