Friendly Neighborhood Spider-Man, Vol. 1 #20 (2007)

Back In Black - Running Out Of Time
Time is running short for 'Miss Arrow, the spider-being created by the nature of Peter's rebirth. In order to insure her survival she has to mate, and she's set her sights on Flash Thompson but he's constantly surrounded by other women. The need to mate is overpowering, and ultimately would be the end of Flash. Can Peter find out what's going on in time to save his friend's life?
Release Date: 2007