Adventures of Superman, Vol. 1 #648A (2006)

Infinite Crisis - Look... Up in the Sky
Chemo, the living weapon, has been dropped into the heart of the city of Bludhaven. Over a hundred thousand souls died in the initial attack. Moments later, Superman is on the scene, working to rescue survivors wherever he can find them. He's followed quickly by waves of others coming to the beleaguered city's aid.
Release Date: 2006