Fantastic Four, Vol. 3 #558 (2008)

Death of the Invisible Woman, Part 1: The New Defenders
Dr. Doom has arrived in the Baxter Building, asking for the help of Reed Richards. Before he can get it, a new group of super powered individuals break into the Baxter Building and kidnap him. The team tries to pull together in the aftermath, hiring a new babysitter in the process, but there are no solid leads just yet. Meanwhile, Johnny has to deal with the relationship he's in right now.
Release Date: 2008