Iron Man, Vol. 4 #16 (2007)

The Initiative - Director of S.H.I.E.L.D.
Tony Stark is back in the lab, working with Maya Lopez to determine how a group of animal rights terrorists got their hands on top of the line biotechnology. Stark is taking the research very seriously, as the altercation involved in stopping the group resulted in the deaths of three men under his command. Meanwhile, the Mandarin (who was arrested in China under a false name) is broken out of his cell by faithful followers.
Release Date: 2007