Justice League of America, Vol. 1 #261 (1987)

Legends - The End of the Justice League of America, Part 4: Last Stand
The unidentified man in a padded cell, thinks back on all of Professor Ivo's crimes, from the creation of Amazo to the deaths of the Justice League members while Ivo, dismayed with yet another fruitless psychiatric session, destroys his psychiatrist android. Vixen uses all the animal powers at her disposal to hunt down Professor Ivo and finally finds him. Ivo sets a dozen androids against her and she battles them as best she can while J'onn J'onzz arrives and tries to help. Temporarily incapacitated by Ivo, J'onn watches as Vixen rises from the androids and attacks Ivo, ripping his head off, revealing him to be an android as well. She opens an adjacent room where they find the padded cell and the real Professor Ivo, clearly insane. J'onn and Vixen return to the headquarters of the League where she decides that she has had enough and leaves, bringing to an end the Justice League of America.
Release Date: 1987