Deadpool, Vol. 3 #6 (2009)

Dark Reign - How Low Can You Go?, Part 1: Dead In the Water
Deadpool awakens to find himself less dead than he was shortly after he encountered Tiger Shark. Thanks to his healing factor, he's not dead anymore, which has really frustrated Tiger Shark's employer, prompting him to call for a more decisive job. Deadpool is facing off against his foe, when a certain palindromic pal comes to the rescue.
Release Date: 2009