Deadpool, Vol. 3 #3 (2008)

Secret Invasion - One of Us, Part Three: The Last Refuge of a Scoundrel
Deadpool's dastardly plan is coming to fruition. All he needs to do to succeed is kill a superskrull, survive an encounter with several Skrull clones based on his own abilities, deal with the Skrull scientist who created them, finish his mission for Nick Fury, and then get off the Skrull war vessel. Piece of cake, right?
Release Date: 2008