Ultimate X-Men, Vol. 1 #94 (Cvr A) (2008)

Ultimatum - Absolute Power, Part 1
A softball game the X-Men are playing is disrupted by Alpha Flight, a Canadian superteam with five members. Those five take out 25 X-Men with ease, and leave with Northstar in custody. Colossus takes this hard. Learning that one of the reasons Alpha Flight worked so well is their use of mutant growth hormone in a drug called "Banshee," the X-Men are divided over whether or not they should use the drug themselves. Colossus has been secretly using the drug for the entire time the X-Men have known him, and he's assembled others who agree with his stance and plan to mount a rescue mission.
Release Date: 2008