Friendly Neighborhood Spider-Man, Vol. 1 #11 (2006)

Spider-Man Unmasked - I Hate A Mystery, Part 1
Peter's life isn't getting any easier now that the world knows that he's Spider-Man. There's a huge media circus surrounding the school where he teaches, and parents organizations are putting a lot of pressure on the administration to have him removed from his position for their children's safety. On the day that he decides to resign his teaching position, a new Mysterio with a grudge against Spider-Man shows up looking for payback.
Release Date: 2006