Cable & Deadpool #44 (2007)

Head Games
Deadpool lost his head when he heard Wolverine was going through the Hydra Base Weasel was left at like a hot knife through butter. Literally. Bob plays fumbleruskie with Wade's severed melon as Weasel tries to evade Wolvie long enough to finish outfitting the other Agents with teleporter harnesses. Bob gets Wade's head back in the game and he sets out to convince Wolvie he's got Weasel all wrong until Weasel sets a mass of Hydra agents after them! The agents turn on their teleporters, only to vanish! Given a moment's pause Weasel lets Wolvie in on the secret to send Hydra to Guatanamo. It all seems to be a happy ending until the harness damaged by those pesky adamantium claws throws a glitch that makes Deadpool and Bob pop off to parts unknown.
Release Date: 2007