Ultimate Spider-Man, Vol. 1 #104 (2007)

Clone Saga, Part 8
Peter and Jessica vent their rage all over Doctor Octopus, hitting him hard and fast, knocking him out without witty repartee of any kind. Once he's down, they rush to the Baxter Building to check on MJ, who seems to be fine. After all, Reed Richards and Dr. Storm have developed an agent that can counteract Oz exposure in any individual.
Release Date: 2007