Superman vs. Predator #2 (2000)

Superman Vs. Predator
The Man of Steel is dangerously weakened by a virus of alien origin! Now, he accompanies the S.T.A.R. Labs research team as they escape the prison of a doctor bent on worldwide genocide. Their flight into the dense South American jungle is short-lived, though, as one of their own turns traitor. After a violent encounter with an alien killer that leaves him even weaker than before, Superman must return to the doctor's lair to rescue both the research team and Lois Lane...
Release Date: 2000