The Sensational Spider-Man, Vol. 2 #37 (2007)

Back In Black - The Strange Case of..., Part Three
Peter has finally tracked Zabo's experiments to a hidden subterannean lair where one subject is still being held... one of the students from Peter's science classes. Finding his experiments threatened, Zabo drinks the serum that transforms him once again into Mr. Hyde. Can Spider-Man stop the rage-fueled Hyde in such close quarters?
Release Date: 2007