Iron Man, Vol. 4 #1 (2004)

The Extremis, Part One
Tony is going about his business as usual, trying to make the world a better place whie still dealing with the ghosts of his past. One such ghost, named Maya Hanson, calls him out of the blue. She's working on a project named Extremis, and a sample's been stolen. Unknown to either of them, the sample has been administered to an individual in an abandoned warehouse.
Release Date: 2004